This product provides a pharmaceutical grade, stabilized SAMe manufactured under low temperature and low humidity conditions. An enteric tablet coating is applied to further ensure a biologically active product. This SAMe is provided in individual foil blister packets to maximize product stability. Each tablet contains a full 200 mg of elemental SAMe from 400 mg SAMe tosylate disulfate.
An impressive amount of research and long history of clinical use documents the benefits of SAMe. As a modulator of cell membrane fluidity and neurochemical activity in the central nervous system, it helps support mood and optimal brain function. The sulfur in SAMe is used to help build cartilage and strong joints and for synthesis of taurine and glutathione, used in liver detoxification processes.
SAMe also helps synthesize polyamines required for normal cell growth. The reactive nature of SAMe prevents it from being used in combination nutrient products, but it can be stabilized as a single ingredient with careful manufacturing and an enteric tablet coating.
Biochemically, the SAMe molecule donates methyl groups to create other important compounds in a process called methylation. Methyl groups are crucial for formation of cell components including proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes. Creatine, involved in energy production, and melatonin are also formed from SAMe. The sulfur content of SAMe is used to support synthesis of cartilage, ligaments, tendons, and bones and to form substances such as glutathione, cysteine, and taurine that detoxify foreign substances in the liver.
Facts and Functions
SAMe (S-adenosyl-L-methionine) is a natural compound made in the body from the essential amino acid L-methionine. It is involved in a number of body processes, including liver detoxification, bone and joint health, and brain function. Although SAMe can be synthesized in the body, deficiencies of methionine, folic acid, or vitamin B12 can reduce SAMe to unhealthy levels. It can also be depleted during liver dysfunction or other conditions. Replenishment of SAMe using dietary supplements has beneficial actions in patients with depression, osteoarthritis, liver disorders, and fibromyalgia.
SAMe can be taken to support joint function, mood regulation, and liver detoxification processes. Individuals being treated for neurological conditions, including those using prescribed medications such as antidepressants, serotonin reuptake inhibitors, and MAO inhibitors, should consult their healthcare professional before using this product. Individuals with bipolar disorder or manic depression should not be take SAMe unless under medical supervision.